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Best Parasite Treatments for Aquariums: Our Top Picks 2024

The unfortunate reality is that parasitic infections can quickly take hold in any aquarium. The trick is to purchase the right parasitic treatment to ensure that your fish are healthy and happy. This is what we are here to do today, to help you find the best parasite treatments for aquariums available on the market.

Best Parasite Treatments for Aquariums

Top 5 Best Parasite Treatments for Aquariums: Reviews

Let’s get to it and take a look at the top 5 parasite treatments for aquariums. 

Disclaimer: The information provided on Aquarium Genius is for general informational purposes only and is not intended as veterinary advice. If your fish or other aquatic animals are showing signs of illness, please consult with a qualified veterinarian in your area for professional guidance and care. Always prioritize the health and well-being of your pets by seeking expert advice.

1. Hikari Prazipro: Our Top Pick

Hikari Prazipro 16oz
  • Ready To Use Liquid Concentrate For Fresh Water and Marine Aquariums
  • Treats Flukes, Tapeworm, Flatworms, Turballarians, and Iasis

Here we have a parasitic aquarium treatment designed to remove flukes, tapeworm, flat worms, turbellarians, and lasis from the water. These are all very specific types of parasites that can easily infest an aquarium and terrariums, therefore making this an essential treatment. This is designed to be used in aquariums and can also be used for turtle tanks.

Something that stands out about this product is that it does not negatively impact your biological filtration and will not kill off beneficial bacteria required for the nitrogen cycle. Keep in mind that it can be used for marine, freshwater, and pond environments. It is safe for all environments, and will not negatively impact your fish whatsoever.

This particular bottle is designed to treat up to 1920 gallons, so it should be more than enough for any home aquarium, and should even be enough for most home ponds. Just be sure to follow all of the instructions as listed on the packaging to ensure that you keep your fish safe and healthy.


  • Effective treatment of many parasites
  • Cost effective
  • Easy to use
  • One bottle treats nearly 2,000 gallons
  • Works as advertised


  • May not kill all parasites

If you’re just looking for a good all-around parasite treatment for your aquarium, this is the number one option we would recommend above all others.

2. API General Cure Freshwater and Saltwater Fish Powder Medication

API GENERAL CURE Freshwater and Saltwater Fish Powder Medication 10-Count Box
  • Contains one (1) API GENERAL CURE Freshwater and Saltwater Fish Powder Medication 10-Count Box
  • Rapidely eliminates parasitic fish disease.

Here we have another aquarium parasite treatment, with this one coming from a highly trusted brand name. What’s really cool is that you get a total of 10 tabs in this package, with each one being more than enough to treat any home aquarium up to several hundred gallons in size.

This means that you get a total of 10 treatments, so this product should last for a very long time. Technically speaking, you need to use two packets every 48 hours when you see that there are any parasites or symptoms of fungal infections.

API is designed to treat parasites that may cause swollen abdomens, skin flukes, gill flukes, and can also treat wasting disease, hole in the head, and others. 

In general, this product should cure a wide variety of parasitic infections with ease. As is the case with any such product, always be sure to follow all of the directions that’s listed on the packaging to ensure that your fish are totally safe.


  • Kills many parasites
  • Safe for fish
  • Good price
  • Easy to use
  • Long lasting


  • Unclear as to exactly which parasites it kills

If you notice that your fish are suffering from any of the parasitic infection symptoms as listed above, then this is a great product for you to consider.

3. KORDON Rapid CURE # 37911 Ich & Parasite Treatment

KORDON Rapid CURE # 37911 Ich & Parasite Treatment, 0.75 Ounce
  • RAPID RELIEF: Provides relief from surface itching and treats common symptoms like white spots,...
  • COMPRENSIVE TREATMENT: Treats Ich infections, fin damage, and external Protozoan parasites,...

If you notice that your fish seem to be suffering from some kind of parasites or ich, then here we have a fantastic treatment for you to check out. Now, keep in mind that this particular product is designed specifically for protozoan parasites, not all types of parasites. With that being said, as far as protozoan parasites go, this is by far one of the most powerful and effective products.

It should be able to kill them in just a couple of days. Here, you are supposed to use one drop per every gallon of aquarium water, and you need to do so three times per day. 

What is convenient is that you will see that treated water turns blue during the treatment cycle, so you can see just how effective the product is. This lets you see that all of your tank water is being treated at once.

What is really neat is that this liquid is easily removed from your aquarium through some simple carbon filtration, so whenever you think that the parasitic infection is taken care of, you can increase carbon filtration to remove any remnants from your aquarium. The whole bottle should be able to treat 400 gallons of aquarium water, and it should work in as little as 48 hours.


  • Easy to use
  • Fast acting
  • Goes a long way
  • Cost effective


  • Only for protozoan parasites

If you notice that your aquarium is suffering from an invasion of protozoan parasites, then it’s time to try this product.

4. Herbtana Natural Parasite Remover for Home Aquariums

MICROBE-LIFT HERB16 Herbtana Immune Booster and Natural Parasite Remover for...
  • BOOST FISH HEALTH: Herbtana is a 100% natural expellant for parasitic diseases; It provides a...
  • WHAT TO WATCH FOR: Parasitic infections are characterized by symptoms such as: milky skin, flashing...

Here we have a parasite treatment solution that can remove many parasites from the water, including skin flukes, gill flukes, Ich, Oodinium, Costia, Chilodonella and Trichodina. As you can see, not only does this product target a variety of parasites, but it also helps remove other issues from the equation.

Something you need to keep in mind before using this product is that you first need to turn off your protein skimmer, ozone generator, and UV sterilizer. All three of these pieces of equipment will effectively destroy the functionality of this product. With that being said, it is one of the most effective products out there.

This product forces all of the parasites to live outside of the fish, in the aquarium water, at which point they will die.

What is also beneficial about this liquid treatment is that it provides a herbal and immune enhancing stimulant to your fish. Therefore, not only does it take care of current parasitic infections, but it also helps make your fish much healthier. A big benefit here is that it can be used in both freshwater and saltwater environments.


  • Effective against most parasites
  • Easy and fast
  • God price
  • Ideal for freshwater and saltwater tanks


  • May negatively impact the nitrogen cycle

If you need a parasitic treatment option that works well for both freshwater and saltwater tanks, then this is likely the best one out there.

5. Microbe-Lift Lice & Anchor Worm

MICROBE-LIFT Remover and Treatment for Lice and Anchor Worms in Fish Tanks, 16oz
  • REMOVES LICE AND ANCHOR WORMS: Our fish tank treatment will remove is an effective lice and anchor...
  • BIOLOGICAL FILTRATION SAFE: The MICROBE-LIFT lice and anchor worm treatment will not harm biological...

As you can probably tell by the name of it, here we have a parasitic treatment that is specifically designed to remove anchor worms and lice from the water and your fish. No, it does not work for any other parasites but the two just listed above.

That said, it does work for both freshwater and saltwater tanks, and it works well for ornamental pond fish, reptiles, amphibians, and tropical fish.

All you have to do is put the appropriate amount of this product in the water, according to the directions I’ve provided on the bottle itself. It should work within just a couple of days, and a little bit should go a very long way.


  • Fast and effective
  • Safe for most fish
  • Doesn’t cost too much


  • May negatively affect water chemistry

If your fish had lice or anchor worms, then this is the product that you need.

Best Parasite Treatments for Aquariums Buyers Guide: What to Look Out For

Before you purchase the first parasite treatment for aquariums that you come across, there are some important considerations you should keep in mind.

The Parasites

First and foremost, not all parasite treatments are designed to treat all parasites. There are many different parasite treatments out there, and many of them work for a variety of parasites, but not all of them. 

Therefore, you always need to read the label first to see exactly which parasites the treatment in question is designed for. If the parasite isn’t listed on the label, then move on and find a different product.

The Type of Fish

Although parasite treatments for aquariums are generally designed more for specific parasites than they are fish, this is still something to keep in mind. 

In other words, some treatments may say that they are ideal for pond fish, some are better for tropical fish, some for marine fish, and so on and so forth. 

Therefore, you always want to make sure that the treatment in question is designed for your specific fish, or more importantly, that it won’t harm your fish.


You might also want to pay attention to just how effective the product in question is, and of course, we’ve chosen all of the best ones here today. Some products may only remove a certain amount of the parasites from the water, whereas other products may remove all of the parasites. 

Aquarium water fish care and treatment of diseases algae and medicine tropical

You also have to keep timing in mind. Some parasite treatments may work in as little as a couple of days, whereas others may take weeks. Of course, time is generally of the essence so the faster the better.

Amounts and Costs

You also want to examine how much of each parasite treatment you get in relation to the cost of said treatment. Simply put, some products are much more expensive than others, rendering them relatively ineffective in terms of your budget. If there are two products that do the same things, then there is no sense in paying more for the more expensive one.